Combinative Particle Size Reduction Technologies for the Formulation of Poorly Soluble Drugs
نویسندگان
چکیده
1. Salazar, Jaime; Müller, Rainer H.; Möschwitzer, Jan P., (2009), “Systematic investigationto establish optimal process parameters for a novel particle size reduction method”, AnnualMeeting of the German Pharmaceutical Society (DPhG), Jena/Germany, September 28 –October 1, 2009. Poster presentation, abstract C48, booklet page 45. 2. Salazar, Jaime; Ghanem, Antoine; Müller, Rainer H.; Möschwitzer, Jan P., (2010),“Influence of freeze drying with organic solvents on the particle size reduction effectiveness of poorly soluble compounds for solubility and bioavailability enhancement”, DrugTransport and Delivery, Swedish Academy of Pharmaceutical Sciences and CRS NordicChapter, Gothenburg/Sweden, June 28-29, 2010. Poster presentation, abstract 25, bookletpage 52.
منابع مشابه
Combinative Particle Size Reduction Technologies for the Production of Drug Nanocrystals.
Nanosizing is a suitable method to enhance the dissolution rate and therefore the bioavailability of poorly soluble drugs. The success of the particle size reduction processes depends on critical factors such as the employed technology, equipment, and drug physicochemical properties. High pressure homogenization and wet bead milling are standard comminution techniques that have been already emp...
متن کاملNanosized Technological Approaches for the Delivery of Poorly Water Soluble Drugs
A major hurdle in pharmaceutical formulation is water insolubility of most of drugs affecting their stability and bioavailability. If the drug is also insoluble in organic medium, it is difficult to deliver it in a sufficiently bioavailable form and hence it is a great challenge to formulation researchers to overcome such difficulty. Although some approaches are available for enhancing th...
متن کاملEnhanced dissolution rate of tadalafil nanoparticles prepared by sonoprecipitation technique: optimization and physicochemical investigation
Nanocrystals of tadalafil, a poorly water-soluble drug, were successfully prepared by sonoprecipitation technique for improving the solubility and dissolution rate. Tween80 was selected as an efficient surfactant to inhibit aggregation in stabilization of drug nanocrystals. Response surface methodology based on central composite design (CCD) was utilized to evaluate the formulation factors affe...
متن کاملEnhanced dissolution rate of tadalafil nanoparticles prepared by sonoprecipitation technique: optimization and physicochemical investigation
Nanocrystals of tadalafil, a poorly water-soluble drug, were successfully prepared by sonoprecipitation technique for improving the solubility and dissolution rate. Tween80 was selected as an efficient surfactant to inhibit aggregation in stabilization of drug nanocrystals. Response surface methodology based on central composite design (CCD) was utilized to evaluate the formulation factors affe...
متن کاملEvaluation of Carbamazepine (CBZ) Supersaturatable Self-Microemulsifying (S-SMEDDS) Formulation In-vitro and In-vivo
The supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of surfactant and a water-soluble polymer (precipitation inhibitor or supersaturated promoter) to prevent precipitation of the drug by generating and maintaining a supersaturated state in-vivo. The supersatur...
متن کامل